Even though 3D printing has developed in bounds and leap in the past years, utilizing it to print functioning human organs is the far-flung dream. Currently, on the other hand, scientists are bringing the dream closer.
Cardiovascular disease is the main cause of death in the United States.
Centers for Disease Control and Prevention
As per the Centers for Disease Control and Prevention (CDC), where 6,50,000 people in the U.S. die because of heart disease every year. It has developed to the final stages where the option for treatment is a heart transplant. As there are few heart donors, where the delay for life-saving transplant is long.
Researchers are powerful in finding ways of repairing the heart tissue to postpone or remove the need for a transplant.
For example, the surgeons can implant the material in the heart where it can form the provisional scaffold to help cells and fuel the cellular organization.
Cardiac tissue engineering is having several problems, initially, researchers require to find the type of material that the body will not accept. Scientists are trying the range of methods and materials where the perfect candidates are cells from the body of the patient.
In the current year, scientists have made progress for the artificially replicating human tissue.
A team of researchers from Tel Aviv University in Israel has considered this work further and encouraging tissue engineering to the next level.
“This is the first time which has positively printed and engineered the complete heart complete with cells, chambers, ventricles and blood vessels”.
Researchers have constructed the revolutionary approach that permits them to generate the nearest thing to the artificial heart to date.
The first step is to do the biopsy of fatty tissue from the patient. And then separate the cellular material from non-cellular material.
Scientists have redesigned the cells of fatty tissue for becoming the pluripotent stem cells in developing the range of cell types essential for growing heart.
The non-cellular material contains the structural components like collagen and glycoproteins and researchers are modified to turn them in “bio-ink”. They mix the bioink with the stem cells where the cells are differentiated into the endothelial or cardiac cells. Where researchers can use to generate cardiac patches involving blood vessels.
Prof. Dvir claims, “This heart is made from human cells and patient-specific biological materials. In our process, these materials serve as the bio-inks, substances made of sugars and proteins. Also, that can use for 3D printing of complex tissue models”.
He continues by saying that “People have managed to 3D-print the structure of a heart in the past. But not with cells or with blood vessels. Our results demonstrate the potential of our approach for engineering personalized tissue and organ replacement in the future.”
To validate the perspective of technique where researchers created the small and anatomically accurate heart. That filled with cells and blood vessels accordingly.
The next task is critical as per Prof. Dvir and claims to show them to perform like hearts. And clarifies that there is “need to develop the printed heart further. The cells need to form a pumping ability; they can currently contract, but we need them to work together”.