Scripps Research scientists, influenced by the sophisticated electrochemistry of the batteries, developed a battery-like system that permits them for making development for the medicines production.
The new method evades the risks of safety-related with the kind of chemical reaction called dissolving metal reduction that is mostly used for producing compounds that are used in the medicines production. The method will provide huge benefits on the recent methods of manufacturing of chemicals, which has mainly been sidelined because of the safety considerations.
Phil Baran, holding the Darlene Shiley Chair in Chemistry at Scripps Research claims that “The same types of batteries we use in our electric cars today were far too dangerous for commercial use a few decades ago, but now they are remarkably safe thanks to advances in chemistry and engineering”. “By applying some of the same principles that made this new generation of batteries possible, we have developed a method to safely conduct powerfully reductive chemical reactions that have very rarely been used on a large-scale because — until now — they were too dangerous or costly”.
The strongest reactions and the illustrative examples of the lessening chemistry that chemists are using for the manufacturing of new molecules is the Birch reduction that was hugely established by Australian chemist Arthur Birch. The decreasing reaction includes softening of the sensitive metal in liquid ammonia to operate the ring-shaped molecules that are used as the base for the production of the chemical products, comprising drug molecules.
The process is calling for the condensation of ammonia or the equivalent compounds that are volatile, toxic and corrosive and mixing it with metals like lithium that are disposed to abounding into flames if unprotected to air. The procedure can take place at severe cold temperatures, needing expensive specialists and equipment.
An exceptional instance of using the dissolving metal reduction in the manufacturing of the pharmaceutical compound that was used in development at Pfizer, a notable achievement in chemical manufacturing requiring the herculean effort. The system producing compound on the large scale require adequate gaseous ammonia to fill three Boeing 747 airliners and must be accompanied at extremely less temperature.
The lithium-ion batteries are used in modern electronics like electric cars, laptop computers and mobile phones are dependent on the advances in the inner component known as solid electrolyte interphase (SEI). The SEI is the protective layer forming one of the electrodes in Li-ion when the battery is primarily charged and permits the battery to get recharged.
Soloman Reisberg, a graduate student in Baran Lab claims that “In many ways, you’re looking at similar situations powerful reactions that, when effectively harnessed, can provide tremendous utility”. “The team took advantage of the hard-won knowledge about the conditions that make reductive electrochemistry in batteries practical and used that knowledge to rethink how deeply reductive chemistry could be used on a large scale.”