Fungal species of genus Aspergillus is producing Aflatoxins that are enormously toxic chemicals.

However, the toxic elements present in the manufacturing and processing stages of various crops as contaminants and the poultry feed. Although, aflatoxins are causing dangerous economic misplacement in livestock and poultry industries.

The most important presence of Aflatoxins comprises of G1, G2, B1, and B2, where AFB1 is the main biological poisonous constituent.

This is causing different effects in poultry like liver pathology, poor performance, changes in relative organ weights and immune suppression.

However, it is causing liver cancer in humans due to the small amount of Aflatoxins and metabolites existing in edible tissues.

The efficiency of the sodium calcium aluminosilicate on Aflatoxins

As HSCAS (hydrated sodium calcium aluminosilicate) is acting as the binding agent of a toxin.

Action Mechanism

However, HSCAS, phyllosilicate clay is tightly binding and immobilizing aflatoxins in the gastrointestinal tract of birds.

Thus, the process is famous as adsorption. Hence, it is leading to the detoxification of mycotoxins with the procedure of adsorption.

In addition, research with molecular modeling is assessing that aflatoxin is binding to HSCAS attributing to the chemisorption. However, chemisorption of aflatoxin at the surface in the interlamellar region of HSCAS. Hence, the external surface of the clay is accountable for minor adsorption of toxins. Thus, HSCAS and AFB1 are having a fast reaction reaching the equilibrium after around 30 minutes.

Because of the reaction, almost 200-250 nmol of aflatoxins are binding per milligram of HSCAS. Thus, HSCAS is weakening the effects of the growth-inhibitor of AFB1 on increasing the chicks by around 50-68%.

Impact of HSCAS on the weight of body, lesions and food efficiency

Adding HSCAS is reducing the poisonousness of aflatoxin and decreasing the effect on gaining the weight by around 70%.

Thus, comparative weight is substantially increasing in kidney, spleen, heart, and liver by aflatoxin. However, the comparative weight of bursa is substantially decreasing by aflatoxin.

Although, HSCAS to diet is containing AF, are diminishing the effects of AF on the relative weights of kidney, liver, spleen, gizzard, and heart. However, HSCAS is not having a negative effect on the efficacy of feed utilization and mortality rate. This, reduces the rate of mortality regarding 29% are getting AF with HSCAS.

Impacts of HSCAS on the biochemistry of serum

HSCAS is protecting the decrease in the concentration of serum glucose in the consuming diet of chicks with aflatoxins.

Similarly, HSCAS is partially protecting against reducing the concentration of cholesterol, total protein, albumin, triglycerides, and corpuscular volume.